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2023-05-28T18:18:14Z

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{{Documentation subpage}}

{{Lua|Module:Infobox|Module:Check for unknown parameters}}

== Usage ==
<syntaxhighlight lang="wikitext">
{{Infobox receptor
| name = 
| signal transduction = 
| primary endogenous agonist = 
| primary endogenous agonists= 
| agonists = 
| antagonists = 
| inverse agonists = 
| PAMs = 
| NAMs = 


| IUPHAR Target ID = 
| DrugBank Polypeptides ID = 
| HMDB Protein ID = 
}}
</syntaxhighlight>

==Parameter notes and examples==
{{Infobox receptor
| name = Beta-2 adrenergic receptor
| signal transduction = Primary: [[Gs alpha subunit|Gs]] Secondary: [[Gi alpha subunit|Gi/o]]
| primary endogenous agonists = [[epinephrine]], [[norepinephrine]]
| agonists = [[isoprenaline]], [[salbutamol]], [[salmeterol]], [[Beta2-adrenergic agonist#Types|others]]
| antagonists = [[carvedilol]], [[propranolol]], [[labetalol]], [[Beta blocker#Examples|others]]
| inverse agonists = N/A
| PAMs = [[zinc|Zn2+]] (low concentrations)
| NAMs = [[zinc|Zn2+]] (high concentrations)
| IUPHAR Target ID = 29
| DrugBank Polypeptides ID = P07550
| HMDB Protein ID = HMDBP01634
}}
{{Infobox receptor
| name = Trace amine-associated receptor 1
| signal transduction = [[Gs alpha subunit|Gs]], [[Gq alpha subunit|Gq]], [[G protein-coupled inwardly rectifying potassium channel|GIRKs]], [[β-arrestin 2]]
| primary endogenous agonists = [[tyramine]], {{nowrap|[[β-phenylethylamine]]}}, [[octopamine]], [[dopamine]]
| agonists = Endogenous: [[trace amine]]s Exogenous: [[RO5166017]], [[amphetamine]], [[methamphetamine]], [[TAAR1#Synthetic|others]]
| antagonists = None characterized
| inverse agonists = [[EPPTB]]
| PAMs = N/A
| NAMs = N/A
| IUPHAR Target ID = 364
| DrugBank Polypeptides ID = Q96RJ0
| HMDB Protein ID = HMDBP10805
}}
Parameters are:{{anchor|Parameters}}
*{{para|name}} (infobox name defaults to {{tlx|PAGENAME}} if excluded)
*{{para|signal transduction}}
*{{para|primary endogenous agonist}} OR {{para|primary endogenous agonists}} (produces singular vs plural output)
*{{para|agonists}}
*{{para|antagonists}}{{#tag:ref|NOTE: this field is listed as "Antagonists" or "Neutral antagonists" depending upon the input for {{para|inverse agonists}}: it's listed as {{nowrap|"[[Neutral antagonist]]s"}} whenever that parameter IS NOT either missing in the template call or included with either of these inputs: {{para|inverse agonists}} OR {{para|inverse agonists|N/A}}. Compare how the "Antagonists" field is listed in the example templates for beta-2 adrenoceptors and TAAR1 (see right).|group="note"}}
*{{para|inverse agonists}}
*{{para|PAMs}}
*{{para|NAMs}}
*{{para|IUPHAR Target ID}}
*{{para|DrugBank Polypeptides ID}}
*{{para|HMDB Protein ID}}
;Notes
{{Reflist|group=note}}

===IUPHAR Target ID===
The input for this parameter should be the number listed at the end of the following url for the receptor's Guide to Pharmacology page: <code><nowiki>http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=</nowiki></code>

For example, the "β2-adrenoceptor" webpage is <code>http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=29</code>, so the parameter input should be {{para|IUPHAR Target ID|29}}.

===DrugBank polypeptides ID===
To find the corresponding webpage to link to with this parameter, go to https://www.drugbank.ca/ and select "Targets", then search for the receptor. This will take you to a "Bio-entities" page (e.g., [https://www.drugbank.ca/biodb/bio_entities/BE0001044 the corresponding page for TAAR1]). The 4th row listed on this page is "Polypeptides"; click the "Details" link in this row, which will take you to the DrugBank Polypeptides page for the receptor (e.g., [https://www.drugbank.ca/biodb/polypeptides/Q96RJ0 TAAR1's DrugBank Polypeptides page]).

Copy the string at the end of the <code><nowiki>https://www.drugbank.ca/biodb/polypeptides/</nowiki></code> url of the page you arrive at and paste it into the {{para|DrugBank Polypeptides ID}} parameter.

For example, for TAAR1, the webpage is <code>https://www.drugbank.ca/biodb/polypeptides/Q96RJ0</code> – so the parameter input is {{Para|DrugBank Polypeptides ID|Q96RJ0}}.

===HMDB Protein ID===
To find the corresponding webpage to link to with this parameter, go to http://www.hmdb.ca/ and select "proteins" in the drop-down menu located at the top of the webpage, then search for the receptor. This will take you to the HMDB webpage for the receptor; the very first row listed on this page is "HMDB Protein ID". Copy/paste the alphanumeric string located to the right of that label into the {{para|HMDB Protein ID}} parameter.

For example, for the Beta-2 adrenergic receptor, the corresponding webpage is <code>http://www.hmdb.ca/proteins/HMDBP01634</code>, the HMDB Protein ID is listed as "HMDBP01634", so the input for this parameter should be {{para|HMDB Protein ID|HMDBP01634}}.

== Tracking categories ==
* {{clc|Pages using infobox GPCR with unknown parameters}}
* {{clc|Pages with Infobox medical condition using multiple parameters for one}}

<includeonly>{{sandbox other||

[[Category:Pharmacology templates]]
[[Category:Templates that add a tracking category]]
}}</includeonly>

Template:Infobox receptor/doc - Revision history

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